CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.360 | Dihydrodipicolinate Reductase; domain 2 |
|
3.30.360.10 | Dihydrodipicolinate Reductase; domain 2 |
Domain Context
CATH Clusters
| Superfamily | Dihydrodipicolinate Reductase; domain 2 |
| Functional Family | D-erythrose-4-phosphate dehydrogenase |
Enzyme Information
| 1.2.1.72 |
Erythrose-4-phosphate dehydrogenase.
based on mapping to UniProt P0A9B6
D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH.
-!- Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate. -!- Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.
|
UniProtKB Entries (1)
| P0A9B6 |
E4PD_ECOLI
Escherichia coli K-12
D-erythrose-4-phosphate dehydrogenase
|
PDB Structure
| PDB | 2X5J |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Characterization of Erythrose-4- Phosphate Dehydrogenase from Escherichia Coli: Peculiar Features When Compared to Phosphorylating Gapdhs
To be Published
|
