CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.60 | Penicillin V Acylase; Chain A |
|
3.60.60.10 | Penicillin V Acylase; Chain A |
Domain Context
CATH Clusters
| Superfamily | Penicillin V Acylase; Chain A |
| Functional Family | Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form |
Enzyme Information
| 2.3.1.164 |
Isopenicillin-N N-acyltransferase.
based on mapping to UniProt P15802
Phenylacetyl-CoA + isopenicillin N + H(2)O = CoA + penicillin G + L-2- aminohexanedioate.
-!- Proceeds by a two stage mechanism via 6-aminopenicillanic acid. -!- Different from EC 3.5.1.11.
|
UniProtKB Entries (1)
| P15802 |
AAAA_PENCH
Penicillium chrysogenum
Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form
|
PDB Structure
| PDB | 2X1E |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme.
Structure
|