CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.1060 | Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2 | |
1.10.1060.10 | Alpha-helical ferredoxin |
Domain Context
CATH Clusters
Superfamily | Alpha-helical ferredoxin |
Functional Family | Succinate dehydrogenase iron-sulfur subunit SdhB |
Enzyme Information
1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt P07014
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
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UniProtKB Entries (1)
P0AC41 |
SDHA_ECOLI
Escherichia coli K-12
Succinate dehydrogenase flavoprotein subunit
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PDB Structure
PDB | 2WU5 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of the E. Coli Succinate:Quinone Oxidoreductase (Sqr) Sdhd His71met Mutant
To be Published
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