CATH Classification

Domain Context

CATH Clusters

Superfamily Golgi alpha-mannosidase II
Functional Family Glycogen debranching enzyme

Enzyme Information

3.2.1.196
Limit dextrin alpha-1,6-maltotetraose-hydrolase.
based on mapping to UniProt P15067
Hydrolysis of (1->6)-alpha-D-glucosidic linkages to branches with degrees of polymerization of three or four glucose residues in limit dextrin.
-!- This bacterial enzyme catalyzes a reaction similar to EC 3.2.1.33. -!- However, while EC 3.2.1.33 removes single glucose residues linked by 1,6-alpha-linkage, and thus requires the additional activity of EC 2.4.1.25 to act on limit dextrins formed by EC 2.4.1.1, this enzyme removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin without a need for another enzyme.

UniProtKB Entries (1)

P15067
GLGX_ECOLI
Escherichia coli K-12
Glycogen debranching enzyme

PDB Structure

PDB 2WSK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Rationale for the Short Branched Substrate Specificity of the Glycogen Debranching Enzyme Glgx.
Song, H.-N., Jung, T.-Y., Park, J.-T., Park, B., Myung, P.K., Boos, W., Woo, E.-J., Park, K.-H.
Proteins
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