CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1440 | GIY-YIG endonuclease |
|
3.40.1440.40 |
Domain Context
CATH Clusters
| Superfamily | 3.40.1440.40 |
| Functional Family |
Enzyme Information
| 3.1.21.8 |
T(4) deoxyribonuclease II.
based on mapping to UniProt P07059
Endonucleolytic nicking and cleavage of cytosine-containing double- stranded DNA.
-!- This phage T(4) enzyme is involved in degradation of host DNA. -!- The enzyme primarily catalyzes nicking of the bottom strand of double stranded DNA between the first and second base pair to the right of a top-strand CCGC motif. -!- Double-stranded breaks are produced 5- to 10-fold less frequently. -!- It does not cleave the T4 native DNA, which contains 5-hydroxymethylcytosine instead of cytosine.
|
UniProtKB Entries (1)
| P07059 |
END2_BPT4
Escherichia virus T4
Endonuclease II
|
PDB Structure
| PDB | 2WSH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Bacteriophage T4 Endonuclease II Mutant E118A, a Tetrameric Giy-Yig Enzyme.
J.Mol.Biol.
|