CATH Domain 2wp5A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.390	Enolase-like; domain 1
	3.30.390.30	FAD/NAD-linked reductase, C-terminal dimerisation domain

Domain Context

CATH Clusters

Superfamily	3.30.390.30
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q389T8_TRYB2

Trypanosoma brucei brucei TREU927

Trypanothione reductase

PDB Structure

PDB	2WP5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography. Patterson, S., Alphey, M.S., Jones, D.C., Shanks, E.J., Street, I.P., Frearson, J.A., Wyatt, P.G., Gilbert, I.H., Fairlamb, A.H. J.Med.Chem.