CATH Domain 2woaA00

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

3.4.24.65

Macrophage elastase.

based on mapping to UniProt P39900

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.

-!- Belongs to peptidase family M10B.

MMP12_HUMAN

Homo sapiens

Macrophage metalloelastase

PDB	2WOA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Identification of Beta-Hydroxy Carboxylic Acids as Selective Mmp-12 Inhibitors. Holmes, I.P., Gaines, S., Watson, S.P., Lorthioir, O., Walker, A., Baddeley, S.J., Herbert, S., Egan, D., Convery, M.A., Singh, O.M.P., Gross, J.W., Strelow, J.M., Smith, R.H., Amour, A.J., Brown, D., Martin, S.L. Bioorg.Med.Chem.Lett.