CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family

Enzyme Information

1.13.11.48
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase.
based on mapping to UniProt O31266
3-hydroxy-2-methyl-1H-quinolin-4-one + O(2) = N-acetylanthranilate + CO.
-!- Does not contain a metal center or organic cofactor. -!- Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. -!- The enzyme from Arthrobacter sp. can also act on 3-hydroxy-4- oxoquinoline, forming N-formylanthranilate and CO (cf. EC 1.13.11.47), but more slowly.

UniProtKB Entries (1)

O31266
HOD_PAENT
Paenarthrobacter nitroguajacolicus
1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase

PDB Structure

PDB 2WM2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Cofactor-Independent Dioxygenation of N-Heteroaromatic Compounds at the {Alpha}/{Beta}-Hydrolase Fold.
Steiner, R.A., Janssen, H.J., Roversi, P., Oakley, A.J., Fetzner, S.
Proc.Natl.Acad.Sci.USA