CATH Domain 2wlyA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family	Chitinase A

Enzyme Information

3.2.1.14

Chitinase.

based on mapping to UniProt P07254

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.

-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P07254

CHIA_SERMA

Serratia marcescens

Chitinase A

PDB Structure

PDB	2WLY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Chitinase inhibition by chitobiose and chitotriose thiazolines. Macdonald, J.M., Tarling, C.A., Taylor, E.J., Dennis, R.J., Myers, D.S., Knapp, S., Davies, G.J., Withers, S.G. Angew. Chem. Int. Ed. Engl.