CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.309 | Aldehyde Dehydrogenase; Chain A, domain 2 |
|
3.40.309.10 | Aldehyde Dehydrogenase; Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 2 |
| Functional Family | Succinate-semialdehyde dehydrogenase I |
Enzyme Information
| 1.2.1.24 |
Succinate-semialdehyde dehydrogenase (NAD(+)).
based on mapping to UniProt P51649
Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.
-!- This enzyme participates in the degradation of glutamate and 4-aminobutyrate. -!- It is similar to EC 1.2.1.79 and EC 1.2.1.16 but is specific for NAD(+).
|
UniProtKB Entries (1)
| P51649 |
SSDH_HUMAN
Homo sapiens
Succinate-semialdehyde dehydrogenase, mitochondrial
|
PDB Structure
| PDB | 2W8R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Redox-Switch Modulation of Human Ssadh by Dynamic Catalytic Loop.
Embo J.
|
