CATH Domain 2vf0A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P0A884

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_ECOLI

Escherichia coli K-12

Thymidylate synthase

PDB Structure

PDB	2VF0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Role of an Invariant Lysine Residue in Folate Binding on Escherichia Coli Thymidylate Synthase: Calorimetric and Crystallographic Analysis of the K48Q Mutant. Arvizu-Flores, A.A., Sugich-Miranda, R., Arreola, R., Garcia-Orozco, K.D., Velazquez-Contreras, E.F., Montfort, W.R., Maley, F., Sotelo-Mundo, R.R. Int.J.Biochem.Cell Biol.