CATH Domain 2v9yB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.650	Phosphoribosyl-aminoimidazole Synthetase; Chain A, domain 2
	3.90.650.10	PurM-like C-terminal domain

Domain Context

CATH Clusters

Superfamily	PurM-like C-terminal domain
Functional Family	Trifunctional purine biosynthetic protein adenosine-3

Enzyme Information

2.1.2.2	Phosphoribosylglycinamide formyltransferase. based on mapping to UniProt P22102 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
6.3.4.13	Phosphoribosylamine--glycine ligase. based on mapping to UniProt P22102 ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide. -!- Formerly EC 6.3.1.3.
6.3.3.1	Phosphoribosylformylglycinamidine cyclo-ligase. based on mapping to UniProt P22102 ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

UniProtKB Entries (1)

PUR2_HUMAN

Homo sapiens

Trifunctional purine biosynthetic protein adenosine-3

PDB Structure

PDB	2V9Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Studies of Tri-Functional Human Gart. Welin, M., Grossmann, J.G., Flodin, S., Nyman, T., Stenmark, P., Tresaugues, L., Kotenyova, T., Johansson, I., Nordlund, P., Lehtio, L. Nucleic Acids Res.