CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.890 | GHMP kinase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | GHMP kinase, C-terminal domain |
| Functional Family | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
Enzyme Information
| 2.7.1.148 |
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
based on mapping to UniProt O67060
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
|
UniProtKB Entries (1)
| O67060 |
ISPE_AQUAE
Aquifex aeolicus VF5
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
|
PDB Structure
| PDB | 2V2V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase Ispe of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis.
Chemmedchem
|
