CATH Domain 2uw9A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P31751

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P49841

GSK3B_HUMAN

Homo sapiens

Glycogen synthase kinase-3 beta

PDB Structure

PDB	2UW9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery. Saxty, G., Woodhead, S.J., Berdini, V., Davies, T.G., Verdonk, M.L., Wyatt, P.G., Boyle, R.G., Barford, D., Downham, R., Garrett, M.D., Carr, R.A. J.Med.Chem.