CATH Domain 2tptA02

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1030	Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
	3.40.1030.10	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain

Superfamily	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family	Thymidine phosphorylase

2.4.2.4

Thymidine phosphorylase.

based on mapping to UniProt P07650

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

-!- In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6. -!- Formerly EC 2.4.2.23.

TYPH_ECOLI

Escherichia coli K-12

Thymidine phosphorylase

PDB	2TPT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase. Pugmire, M.J., Cook, W.J., Jasanoff, A., Walter, M.R., Ealick, S.E. J.Mol.Biol.