CATH Domain 2tdmA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P00469

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_LACCA

Lactobacillus casei

Thymidylate synthase

PDB Structure

PDB	2TDM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. Finer-Moore, J., Fauman, E.B., Foster, P.G., Perry, K.M., Santi, D.V., Stroud, R.M. J.Mol.Biol.