CATH Domain 2rsyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P32577

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P32577

CSK_RAT

Rattus norvegicus

Tyrosine-protein kinase CSK

PDB Structure

PDB	2RSY
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains. Tanaka, H., Akagi, K., Oneyama, C., Tanaka, M., Sasaki, Y., Kanou, T., Lee, Y.H., Yokogawa, D., Dobenecker, M.W., Nakagawa, A., Okada, M., Ikegami, T. J.Biol.Chem.