CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.572 | Thymidylate Synthase; Chain A | |
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
Functional Family | Possible thymidylate synthase |
Enzyme Information
2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P04818
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
P04818 |
TYSY_HUMAN
Homo sapiens
Thymidylate synthase
|
PDB Structure
PDB | 2RD8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The R163K Mutant of Human Thymidylate Synthase Is Stabilized in an Active Conformation: Structural Asymmetry and Reactivity of Cysteine 195.
Biochemistry
|