CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.20 | Up-down Bundle | |
1.20.910 | Heme Oxygenase; Chain A | |
1.20.910.10 | Heme oxygenase-like |
Domain Context
CATH Clusters
Superfamily | Heme oxygenase-like |
Functional Family | Aminopyrimidine aminohydrolase |
Enzyme Information
3.5.99.2 |
Aminopyrimidine aminohydrolase.
based on mapping to UniProt A8KRL3
(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5- hydroxymethyl-2-methylpyrimidine + ammonia. (2) Thiamine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.
-!- Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.
|
UniProtKB Entries (1)
A8KRL3 |
TENA_HELPX
Helicobacter pylori
Aminopyrimidine aminohydrolase
|
PDB Structure
PDB | 2RD3 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The structural and functional characterization of HP1287
from Helicobacter pylori demonstrates it is a TenA homologue
To be Published
|