CATH Classification

Domain Context

CATH Clusters

Superfamily Heme oxygenase-like
Functional Family Aminopyrimidine aminohydrolase

Enzyme Information

3.5.99.2
Aminopyrimidine aminohydrolase.
based on mapping to UniProt A8KRL3
(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5- hydroxymethyl-2-methylpyrimidine + ammonia. (2) Thiamine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.
-!- Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.

UniProtKB Entries (1)

A8KRL3
TENA_HELPX
Helicobacter pylori
Aminopyrimidine aminohydrolase

PDB Structure

PDB 2RD3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structural and functional characterization of HP1287 from Helicobacter pylori demonstrates it is a TenA homologue
Barison, N., Cendron, L., Trento, A., Angelini, A., Zanotti, G.
To be Published