CATH Domain 2r9kA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.420	Ricin (A subunit); domain 1
	3.40.420.10	Ricin (A subunit), domain 1

Domain Context

CATH Clusters

Superfamily	Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P81446

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P81446

ML1_VISAL

Viscum album

Beta-galactoside-specific lectin 1

PDB Structure

PDB	2R9K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The mistletoe lectin I--phloretamide structure reveals a new function of plant lectins. Meyer, A., Rypniewski, W., Celewicz, L., Erdmann, V.A., Voelter, W., Singh, T.P., Genov, N., Barciszewski, J., Betzel, C.h. Biochem.Biophys.Res.Commun.