CATH Classification

Domain Context

CATH Clusters

Superfamily mRNA triphosphatase Cet1-like
Functional Family

Enzyme Information

3.1.3.33
Polynucleotide 5'-phosphatase.
based on mapping to UniProt Q5UQX1
A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Does not act on nucleoside monophosphates. -!- Induced in Escherichia coli by T-even phages.
2.1.1.56
mRNA (guanine-N(7)-)-methyltransferase.
based on mapping to UniProt Q5UQX1
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
-!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.
2.7.7.50
mRNA guanylyltransferase.
based on mapping to UniProt Q5UQX1
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
-!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.

UniProtKB Entries (1)

Q5UQX1
MCE_MIMIV
Acanthamoeba polyphaga mimivirus
Probable mRNA-capping enzyme

PDB Structure

PDB 2QY2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain.
Benarroch, D., Smith, P., Shuman, S.
Structure