CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.30 | Elongation Factor Tu (Ef-tu); domain 3 |
|
2.40.30.10 | Translation factors |
Domain Context
CATH Clusters
| Superfamily | Translation factors |
| Functional Family | methionine synthase reductase |
Enzyme Information
| 1.16.1.8 |
[Methionine synthase] reductase.
based on mapping to UniProt Q9UBK8
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosylhomocysteine + NADP(+) = 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L- methionine.
-!- The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13. -!- Electrons are transferred from NADPH to FAD to FMN. -!- Formerly EC 2.1.1.135.
|
UniProtKB Entries (1)
| Q9UBK8 |
MTRR_HUMAN
Homo sapiens
Methionine synthase reductase
|
PDB Structure
| PDB | 2QTZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry
Biochemistry
|