CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.718 | Isopropylmalate Dehydrogenase |
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3.40.718.10 | Isopropylmalate Dehydrogenase |
Domain Context
CATH Clusters
Superfamily | Isopropylmalate Dehydrogenase |
Functional Family | Isocitrate dehydrogenase [NADP] |
Enzyme Information
1.1.1.42 |
Isocitrate dehydrogenase (NADP(+)).
based on mapping to UniProt P21954
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.
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UniProtKB Entries (1)
P21954 |
IDHP_YEAST
Saccharomyces cerevisiae S288C
Isocitrate dehydrogenase [NADP], mitochondrial
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PDB Structure
PDB | 2QFX |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction
Protein Sci.
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