CATH Domain 2qdtA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.15	Metallo-beta-lactamase; Chain A
	3.60.15.10	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Context

CATH Clusters

Superfamily	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family	Metallo-beta-lactamase L1 type 3

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P52700

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P52700

BLA1_STEMA

Stenotrophomonas maltophilia

Metallo-beta-lactamase L1 type 3

PDB Structure

PDB	2QDT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Lienard, B.M., Garau, G., Horsfall, L., Karsisiotis, A.I., Damblon, C., Lassaux, P., Papamicael, C., Roberts, G.C., Galleni, M., Dideberg, O., Frere, J.M., Schofield, C.J. Org.Biomol.Chem.