CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1490 | Dna Ligase; domain 1 |
|
3.30.1490.180 | RNA polymerase ii |
Domain Context
CATH Clusters
| Superfamily | RNA polymerase ii |
| Functional Family |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt Q980R2
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (2)
| P58192 |
RPOA2_SACS2
Saccharolobus solfataricus P2
DNA-directed RNA polymerase subunit A''
|
| Q9UXD9 |
Q9UXD9_SACSO
Saccharolobus solfataricus
DNA-directed RNA polymerase subunit F
|
PDB Structure
| PDB | 2PMZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The X-ray crystal structure of RNA polymerase from Archaea
Nature
|
