CATH Domain 2pfdA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.680	Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle

Domain Context

CATH Clusters

Superfamily	Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle
Functional Family	Formimidoyltransferase cyclodeaminase

Enzyme Information

4.3.1.4	Formimidoyltetrahydrofolate cyclodeaminase. based on mapping to UniProt O88618 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH(3). -!- In eukaroytes, occurs as a bifunctional enzyme that also has EC 2.1.2.5 activity.
2.1.2.5	Glutamate formimidoyltransferase. based on mapping to UniProt O88618 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. -!- In eukaryotes occurs as a bifunctional enzyme also having EC 4.3.1.4 activity. -!- Formerly EC 2.1.2.6.

UniProtKB Entries (1)

FTCD_RAT

Rattus norvegicus

Formimidoyltransferase-cyclodeaminase

PDB Structure

PDB	2PFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Anisotropically refined structure of FTCD Poon, B.K., Chen, X., Lu, M., Vyas, N.K., Quiocho, F.A., Wang, Q., Ma, J. To be Published