CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Beta-secretase 1

Enzyme Information

3.4.23.46
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817
BACE1_HUMAN
Homo sapiens
Beta-secretase 1

PDB Structure

PDB 2P8H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1.
Barrow, J.C., Rittle, K.E., Ngo, P.L., Selnick, H.G., Graham, S.L., Pitzenberger, S.M., McGaughey, G.B., Colussi, D., Lai, M.T., Huang, Q., Tugusheva, K., Espeseth, A.S., Simon, A.J., Munshi, S.K., Vacca, J.P.
Chemmedchem