CATH Domain 2p5xB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.950	Maf protein
	3.90.950.10

Domain Context

CATH Clusters

Superfamily	3.90.950.10
Functional Family	Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein

Enzyme Information

2.1.1.-

Methyltransferases.

based on mapping to UniProt O95671

3.6.1.9

Nucleotide diphosphatase.

based on mapping to UniProt O95671

A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.

-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC 3.6.1.19.

UniProtKB Entries (1)

O95671

ASML_HUMAN

Homo sapiens

Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein

PDB Structure

PDB	2P5X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Tchigvintsev, A., Tchigvintsev, D., Flick, R., Popovic, A., Dong, A., Xu, X., Brown, G., Lu, W., Wu, H., Cui, H., Dombrowski, L., Joo, J.C., Beloglazova, N., Min, J., Savchenko, A., Caudy, A.A., Rabinowitz, J.D., Murzin, A.G., Yakunin, A.F. Chem.Biol.