CATH Domain 2ofuA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P06239

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06239

LCK_HUMAN

Homo sapiens

Tyrosine-protein kinase Lck

PDB Structure

PDB	2OFU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity Martin, M.W., Newcomb, J., Nunes, J.J., McGowan, D.C., Armistead, D.M., Boucher, C., Buchanan, J.L., Buckner, W., Chai, L., Elbaum, D., Epstein, L.F., Faust, T., Flynn, S., Gallant, P., Gore, A., Gu, Y., Hsieh, F., Huang, X., Lee, J.H., Metz, D., Middleton, S., Mohn, D., Morgenstern, K., Morrison, M.J., Novak, P.M., Oliveira-dos-Santos, A., Powers, D., Rose, P., Schneider, S., Sell, S., Tudor, Y., Turci, S.M., Welcher, A.A., White, R.D., Zack, D., Zhao, H., Zhu, L., Zhu, X., Ghiron, C., Amouzegh, P., Ermann, M., Jenkins, J., Johnston, D., Napier, S., Power, E. J.Med.Chem.