CATH Domain 2ofpB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	2-dehydropantoate 2-reductase

Enzyme Information

1.1.1.169

2-dehydropantoate 2-reductase.

based on mapping to UniProt P0A9J4

(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH.

UniProtKB Entries (1)

PANE_ECOLI

Escherichia coli K-12

2-dehydropantoate 2-reductase

PDB Structure

PDB	2OFP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of Escherichia coli Ketopantoate Reductase in a Ternary Complex with NADP+ and Pantoate Bound: SUBSTRATE RECOGNITION, CONFORMATIONAL CHANGE, AND COOPERATIVITY. Ciulli, A., Chirgadze, D.Y., Smith, A.G., Blundell, T.L., Abell, C. J.Biol.Chem.