CATH Domain 2nqiA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Calpain-1 catalytic subunit

Enzyme Information

3.4.22.52

Calpain-1.

based on mapping to UniProt P97571

Broad endopeptidase specificity.

-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

P97571

CAN1_RAT

Rattus norvegicus

Calpain-1 catalytic subunit

PDB Structure

PDB	2NQI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries Cuerrier, D., Moldoveanu, T., Campbell, R.L., Kelly, J., Yoruk, B., Verhelst, S.H.L., Greenbaum, D., Bogyo, M., Davies, P.L. J.Biol.Chem.