CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.160 | Double Stranded RNA Binding Domain | |
3.30.160.20 |
Domain Context
CATH Clusters
Superfamily | 3.30.160.20 |
Functional Family | Drosha ribonuclease III |
Enzyme Information
3.1.26.3 |
Ribonuclease III.
based on mapping to UniProt Q9NRR4
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.
|
UniProtKB Entries (1)
Q9NRR4 |
RNC_HUMAN
Homo sapiens
Ribonuclease 3
|
PDB Structure
PDB | 2NA2 |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
Towards understanding Drosha dsRBDs role in Microprocessing
To be Published
|