CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.160.20
Functional Family Putative double-stranded RNA-specific adenosine deaminase

Enzyme Information

3.5.4.37
Double-stranded RNA adenine deaminase.
based on mapping to UniProt P55265
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.

UniProtKB Entries (1)

P55265
DSRAD_HUMAN
Homo sapiens
Double-stranded RNA-specific adenosine deaminase

PDB Structure

PDB 2MDR
External Links
Method SOLUTION NMR
Organism
Primary Citation
A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.
Barraud, P., Banerjee, S., Mohamed, W.I., Jantsch, M.F., Allain, F.H.
Proc.Natl.Acad.Sci.USA