CATH Domain 2le0A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10190	BRCT domain

Domain Context

CATH Clusters

Superfamily	BRCT domain
Functional Family	Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt P27008

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt P27008

UniProtKB Entries (1)

P27008

PARP1_RAT

Rattus norvegicus

Poly [ADP-ribose] polymerase 1

PDB Structure

PDB	2LE0
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Structural studies of the PARP-1 BRCT domain. Loeffler, P.A., Cuneo, M.J., Mueller, G.A., Derose, E.F., Gabel, S.A., London, R.E. Bmc Struct.Biol.