CATH Domain 2lcjA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.16	Endonuclease - Pi-scei; Chain A, domain 1
	2.170.16.10	Hedgehog/Intein (Hint) domain

Domain Context

CATH Clusters

Superfamily	Hedgehog/Intein (Hint) domain
Functional Family

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt Q9V2F4 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.11.1	Exodeoxyribonuclease I. based on mapping to UniProt Q9V2F4 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. -!- Preference for single-stranded DNA. -!- The Escherichia coli enzyme hydrolyzes glucosylated DNA. -!- Similar enzymes; mammalian DNase III, exonuclease IV, T2- and T4-induced exodeoxyribonucleases. -!- Formerly EC 3.1.4.25.

UniProtKB Entries (1)

DP2L_PYRAB

Pyrococcus abyssi GE5

DNA polymerase II large subunit

PDB Structure

PDB	2LCJ
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Structural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II of Pyrococcus abyssi. Du, Z., Liu, J., Albracht, C.D., Hsu, A., Chen, W., Marieni, M.D., Colelli, K.M., Williams, J.E., Reitter, J.N., Mills, K.V., Wang, C. J.Biol.Chem.