CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.160 | Double Stranded RNA Binding Domain | |
3.30.160.20 |
Domain Context
CATH Clusters
Superfamily | 3.30.160.20 |
Functional Family | double-stranded RNA-specific editase 1 isoform X1 |
Enzyme Information
3.5.4.37 |
Double-stranded RNA adenine deaminase.
based on mapping to UniProt Q91ZS8
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.
|
UniProtKB Entries (1)
Q91ZS8 |
RED1_MOUSE
Mus musculus
Double-stranded RNA-specific editase 1
|
PDB Structure
PDB | 2L2K |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove.
Cell(Cambridge,Mass.)
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