CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.420 | Immunoglobulin FC, subunit C |
Domain Context
CATH Clusters
| Superfamily | Immunoglobulin FC, subunit C |
| Functional Family | Receptor protein-tyrosine kinase |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P00533
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P04626 |
ERBB2_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-2
|
PDB Structure
| PDB | 2KS1 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Spatial Structure of the Transmembrane Domain Heterodimer of ErbB1 and ErbB2 Receptor Tyrosine Kinases
J.Mol.Biol.
|
