CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P28522
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P28522
RIPX_MAIZE
Zea mays
Ribosome-inactivating protein

PDB Structure

PDB 2K6H
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of an active mutant of maize ribosome-inactivating protein (MOD) and its interaction with the ribosomal stalk protein P2.
Yang, Y., Mak, A.N., Shaw, P.C., Sze, K.H.
J.Mol.Biol.
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