CATH Domain 2jbmA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1170	Aldehyde Oxidoreductase; domain 3
	3.90.1170.20	Quinolinate phosphoribosyl transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Quinolinate phosphoribosyl transferase, N-terminal domain
Functional Family	Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Enzyme Information

2.4.2.19

Nicotinate-nucleotide diphosphorylase (carboxylating).

based on mapping to UniProt Q15274

Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

-!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.

UniProtKB Entries (1)

Q15274

NADC_HUMAN

Homo sapiens

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

PDB Structure

PDB	2JBM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Kinetic Characterization of Quinolinate Phosphoribosyltransferase (Hqprtase) from Homo Sapiens. Liu, H., Woznica, K., Catton, G., Crawford, A., Bottinf, N., Naismith, J.H. J.Mol.Biol.