CATH Domain 2j9rA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidine kinase

Enzyme Information

2.7.1.21

Thymidine kinase.

based on mapping to UniProt Q81JX0

ATP + thymidine = ADP + thymidine 5'-phosphate.

-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

Q81JX0

KITH_BACAN

Bacillus anthracis

Thymidine kinase

PDB Structure

PDB	2J9R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Studies of Thymidine Kinases from Bacillus Anthracis and Bacillus Cereus Provide Insights Into Quaternary Structure and Conformational Changes Upon Substrate Binding Kosinska, U., Carnrot, C., Sandrini, M.P.B., Clausen, A.R., Wang, L., Piskur, J., Eriksson, S., Eklund, H. FEBS J.