CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Aspartokinase

Enzyme Information

2.7.2.4
Aspartate kinase.
based on mapping to UniProt P08660
ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
-!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.

UniProtKB Entries (1)

P08660
AK3_ECOLI
Escherichia coli K-12
Lysine-sensitive aspartokinase 3

PDB Structure

PDB 2J0X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of R- and T-State Escherichia Coli Aspartokinase III: Mechanisms of the Allosteric Transition and Inhibition by Lysine.
Kotaka, M., Ren, J., Lockyer, M., Hawkins, A.R., Stammers, D.K.
J.Biol.Chem.
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