CATH Domain 2iz1A03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.320	6-Phosphogluconate Dehydrogenase, domain 3

Domain Context

CATH Clusters

Superfamily	6-Phosphogluconate Dehydrogenase, domain 3
Functional Family	6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44

Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).

based on mapping to UniProt P96789

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P96789

6PGD_LACLM

Lactococcus lactis subsp. cremoris MG1363

6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB	2IZ1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structures of a Bacterial 6- Phosphogluconate Dehydrogenase Reveal Aspects of Specificity, Mechanism and Mode of Inhibition by Analogues of High-Energy Reaction Intermediates. Sundaramoorthy, R., Iulek, J., Barrett, M.P., Bidet, O., Ruda, G.F., Gilbert, I.H., Hunter, W.N. FEBS J.