CATH Classification

Domain Context

CATH Clusters

Superfamily Cyanate lyase, C-terminal domain
Functional Family Cyanate hydratase

Enzyme Information

4.2.1.104
Cyanase.
based on mapping to UniProt P00816
Cyanate + HCO(3)(-) + 2 H(+) = NH(3) + 2 CO(2).
-!- This enzyme, which is found in bacteria and plants, is used to decompose cyanate, which can be used as the sole source of nitrogen. -!- The reaction can be considered as the reverse of 'carbamate = cyanate + H(2)O', where this is assisted by reaction with bicarbonate and carbon dioxide, and hence is classified in sub-subclass 4.2.1. -!- Bicarbonate functions as a recycling substrate. -!- Formerly EC 3.5.5.3 and EC 4.3.99.1.

UniProtKB Entries (1)

P00816
CYNS_ECOLI
Escherichia coli K-12
Cyanate hydratase

PDB Structure

PDB 2IVQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Twin Set of Low Pka Arginines Ensures the Concerted Acid Base Catalytic Mechanism of Cyanase
Guilloton, M., Walsh, M.A., Joachimiak, A., Anderson, P.M.
To be Published