CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.190 | Phosphatidylinositol (PI) phosphodiesterase |
Domain Context
CATH Clusters
| Superfamily | Phosphatidylinositol (PI) phosphodiesterase |
| Functional Family | Phosphoinositide phospholipase C |
Enzyme Information
| 3.1.4.11 |
Phosphoinositide phospholipase C.
based on mapping to UniProt P10688
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
|
UniProtKB Entries (1)
| P10688 |
PLCD1_RAT
Rattus norvegicus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
|
PDB Structure
| PDB | 2ISD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
Nature
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