CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Arsenate reductase

Enzyme Information

1.20.4.4
Arsenate reductase (thioredoxin).
based on mapping to UniProt P45947
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H(2)O.
-!- The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin. -!- It has no activity with glutaredoxin (cf. EC 1.20.4.1). -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds. -!- The enzyme also has the activity of EC 3.1.3.48.

UniProtKB Entries (1)

P14949
THIO_BACSU
Bacillus subtilis subsp. subtilis str. 168
Thioredoxin

PDB Structure

PDB 2IPA
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis.
Li, Y., Hu, Y., Zhang, X., Xu, H., Lescop, E., Xia, B., Jin, C.
J.Biol.Chem.
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