CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1000 | HAD superfamily/HAD-like |
Domain Context
CATH Clusters
| Superfamily | HAD superfamily/HAD-like |
| Functional Family | Phosphonoacetaldehyde hydrolase |
Enzyme Information
| 3.11.1.1 |
Phosphonoacetaldehyde hydrolase.
based on mapping to UniProt O31156
Phosphonoacetaldehyde + H(2)O = acetaldehyde + phosphate.
-!- This enzyme destabilizes the C-P bond, by forming an imine between one of its lysine residues and the carbonyl group of the substrate, thus allowing this, normally stable, bond to be broken. -!- The mechanism is similar to that used by EC 4.1.2.13 to break a C-C bond.
|
UniProtKB Entries (1)
| O31156 |
PHNX_BACCE
Bacillus cereus
Phosphonoacetaldehyde hydrolase
|
PDB Structure
| PDB | 2IOF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.
Bioorg.Chem.
|