CATH Domain 2ilxA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1740	2',3'-cyclic nucleotide 3'-phosphodiesterase fold
	3.90.1740.10	2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily

Domain Context

CATH Clusters

Superfamily	2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily
Functional Family	Tetratricopeptide repeat protein 25

Enzyme Information

3.1.4.37

2',3'-cyclic-nucleotide 3'-phosphodiesterase.

based on mapping to UniProt P13233

Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 2'-phosphate.

-!- The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. -!- An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyzes the corresponding 3',5'-cyclic phosphates, more slowly. -!- This latter enzyme has been called cyclic-CMP phosphodiesterase.

UniProtKB Entries (1)

P13233

CN37_RAT

Rattus norvegicus

2',3'-cyclic-nucleotide 3'-phosphodiesterase

PDB Structure

PDB	2ILX
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Solution structure of the catalytic domain of RICH protein from goldfish. Kozlov, G., Denisov, A.Y., Pomerantseva, E., Gravel, M., Braun, P.E., Gehring, K. Febs J.