CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.80 | Alpha-Beta Horseshoe |
|
3.80.10 | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) |
|
3.80.10.10 | Ribonuclease Inhibitor |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease Inhibitor |
| Functional Family | Tyrosine-protein kinase receptor |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04629
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P01138 |
NGF_HUMAN
Homo sapiens
Beta-nerve growth factor
|
PDB Structure
| PDB | 2IFG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
Neuron
|
