CATH Domain 2ibtA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.72

Site-specific DNA-methyltransferase (adenine-specific).

based on mapping to UniProt P14385

S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.

-!- This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5). -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P14385

MTTA_THEAQ

Thermus aquaticus

Modification methylase TaqI

PDB Structure

PDB	2IBT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	2-Aminopurine Flipped into the Active Site of the Adenine-Specific DNA Methyltransferase M.TaqI: Crystal Structures and Time-Resolved Fluorescence Lenz, T., Bonnist, E.Y.M., Pljevaljcic, G., Neely, R.K., Dryden, D.T.F., Scheidig, A.J., Jones, A.C., Weinhold, E. J.Am.Chem.Soc.