CATH Classification

Domain Context

CATH Clusters

Superfamily BRCT domain
Functional Family DNA-directed DNA/RNA polymerase mu

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9NP87
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9NP87
DPOLM_HUMAN
Homo sapiens
DNA-directed DNA/RNA polymerase mu

PDB Structure

PDB 2HTF
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining.
DeRose, E.F., Clarkson, M.W., Gilmore, S.A., Galban, C.J., Tripathy, A., Havener, J.M., Mueller, G.A., Ramsden, D.A., London, R.E., Lee, A.L.
Biochemistry